Thousands of healing benefits from using Aloe Vera are now well documented. Many doctors around the world are actively using Aloe Vera either alongside or as an alternative to conventional treatments where orthodox medicines have failed.

Aloe Vera has been described as a potent natural product which the body recognises. With its synergistic mix of essential vitamins, minerals, proteins and enzymes it can be a very powerful force which helps the body heal itself.

Extensive scientific research in the United States and the former Soviet Union has been conducted to determine the pharmacological basis of Aloe Vera. Hundreds of these scientific studies and journals were reviewed by Dr Bill Coats R.Ph. who then reported in his book "The Silent Healer – A modern study of Aloe Vera" that Aloe Vera has the following properties:

More recently, in 1992, C. Pittman wrote a short review and summary of the stimulatory nature of Aloe Vera on the immune system whereby he concluded:

"Acemannan, (a polysaccharide fraction found in Aloe) has direct effects on the immune system, activating and stimulating macrophages, monocytes, antibodies and T-cells."

Aloe Vera and Gastrointestinal Disorder

For over 300 years the curanderos and curanderas in the Rio Grande Valley of Texas and the northern states of Mexico have recommended internal Aloe gel for "Las enferemedades del estomago y los intestinos, pero especialment para las ulceras." (The diseases of the stomach and intestines, but especially for ulcers). As a result of these anecdotal reports, scientific investigations have been undertaken in animal models (laboratory rats) which have shown that if Aloe gel is administered prior to the ulcer-inducing stress (immobilization), there is an 80% decrease in the number of ulcers formed compared with the control animals given saline instead of the Aloe gel. Similarly, if the Aloe gel was given after the ulcers were formed, healing was three times as fast compared to the healing in the control animals. (Galal et al, 1975)

In a second laboratory investigation, Aloe gel pretreatment was 85% effective in preventing stomach lesions, and 50% better than the controls in healing the gastric ulcerations. (Kandil and Gobran, 1979)

Additional studies showed that a common group of plant constituents, the triterpenes, including lupeol, possess ulceroprotective activity against the formation of gastric ulcerations in albino rats induced by immobilization restraint. (Gupta et al, 1981) Other investigations have shown that Aloe gel preparations contain lupeol as well as other triterpenoids. (Suga and Hirata, 1983)

Aloe gel mixed with heavy liquid petrolatum (2:1) was given to 12 patients, 7 males and 5 females, ages 24 to 84 years, with definitive x-ray evidence of duodenal ulcers. All 12 patients showed complete recovery with no recurrence for at least a year after ulcer healing. This study suffers, however, from the fact that (1) Duodenal ulcers are often self-healing without any treatment, and (2) There was no control group of patients treated in a similar manner without the administration of Aloe. Nonetheless, the physicians who conducted the study represent trained, clinically-experienced observers, and thus even these uncontrolled observations have some scientific merit. (Blitz et al, 1963)

Aloe Vera Atherosclerosis and Coronary Heart Disease

Coronary heart disease associated with the accumulation of blood fats (Lipids) in the lining of the arteries is still one of the major causes of death in the Western world. Several studies in animal models as well as in human subjects have suggested that the ingestion of Aloe gel may have a beneficial effect by lowering serum cholesterol, serum triglycerides, and serum phospholipids, which, when elevated, seem to accelerate the deposition of fatty materials in the large and medium-sized arteries, including the coronary arteries of the heart.

In one study, albino laboratory rats were fed high cholesterol diets with the experimental group fed the polysaccharide (Glucomannan) from Aloe. Compared with the control animals, the group fed the Aloe fraction showed:

The evidence suggests that the ingestion of Aloe gel, may have a salubrious effect on fat (Lipid) metabolism which, if active in human subjects, would tend to decrease the risk of coronary artery disease in people. (Joshi and Dixit, 1986)

Monkeys given Triton, which causes marked increases in blood lipids, were divided into two groups. The first group was given Aloe, while the second group received the drug, clofibrate, which is used clinically to lower serum cholesterol and triglyceride levels. The following data show the reduction in the various parameters compared with the control animals.

There was a marked improvement in the beneficial HDL/Total Cholesterol ratios. (Bixit and Joshi, 1983)

Parameter Aloe Treated Monkeys Clofibrate Treated Monkeys
Total Colesterol 61.7% 47.6%
Triglycerides 37.8% 50.0%
Phospholipids 51.2% 41.7%
Non-Esterified Fatty Acids 45.5% 23.9%

A third investigation was performed studying 5,000 patients who were fed the husks of a local Indian plant, isabgal, which provided fiber, and Aloe gel as a beverage. There were some remarkable effects in three important areas:

  1. Lipid Metabolism
    1. Decreased total cholesterol
    2. Decreased triglycerides
    3. Increased HDL cholesterol
  2. Carbohydrate Metabolism
    1. Decreased fasting blood sugar levels in diabetic patients.
    2. Decreased post-prandial (after a meal) elevation in blood sugar levels in diabetic patients.
  3. Angina pectoris (chest pain from insufficient delivery of oxygen to the heart)
    1. Decreased frequency of anginal attacks.

These data in the human study suggest that the benefit from the regimen, at least in part attributable to the ingested Aloe beverage, may have salubrious effects on several systems in the body. (Agarwal, 1985)

Aloe Vera Anti-Cancer Actions

One of the common experimental cancer models is sarcoma-180. When Aloe was administered to mice bearing S-180 tumors, the tumor growth was inhibited. (Soeda, 1969; Suzuki, 1979)

Similarly, Alexin B, a specific molecule species derived from Aloe, was shown to possess anti-cancer activity against lymphocytic leukemia. (Suzuki, 1979a)

Additional investigations revealed that another molecular species derived from Aloe, Aloctin-A, had anti-tumor activity, but the action was to bolster the immune system rather than a direct anti-tumor activity. (Imanishi et al, 1981)

Aloe Vera and the Immune System

There are several mechanisms which contribute to the immunological protection enjoyed by normal persons. Among these mechanisms the ingestion of bacteria and other potentially harmful agents by certain white blood cells (a process termed phagocytosis) and the formation of antibodies (formed by another group of white cells, the beta-lymphocytes) are probably the most important. Scientific evidence suggests that Aloe gel contains substances which are active both in stimulating phagocytosis as well as stimulating the formation of antibodies.

In one study, the Aloe fractions were shown to increase phagocytosis when injected into guinea pigs. (Stepanava et al, 1977) In another study, mice were injected intraperitoneally with Escherichia coli, which caused a serious infection to develop in the abdominal cavity, namely, peritonitis. Injects of materials from two species of Aloe (Aloe barteri and Aloe ferox) both stimulated phagocytic activity in the animals. (Delaveau et al, 1980) It was demonstrated that phagocytic activity was depressed in adult patients with bronchial asthma. A mixture of amino acids derived from Aloe enhanced the depressed phagocytic function of the white blood cells in these asthma patients. (Yagi et al, 1987) In an additional study when certain materials (lectins) purified from Aloe were added to human lymphocytes raised in tissue cultures, the human white cells were stimulated to produce antibodies. (Suzuki et al, 1979)

Perhaps the most remarkable studies concern the effect of Aloe fractions on the status of patients with HIV which causes AIDS. The polysaccharide fraction of Aloe was shown to exhibit antiviral activity and enhance cell function. The polysaccharide was given orally, 250 milligrams four times a day, to 8 patients with ARC (AIDS Related Complex), with Walter Reed staging from 3 to 6. Eight of eight patients showed improvement within 90 days of therapy with an average reduction of 2 Walter Reed stages. Fever and night sweats were eliminated in all patients; diarrhea was alleviated in two of three patients, and opportunistic infections (which are usually responsible for the death of the AIDS patient) were controlled or eliminated in six of eight patients. Two patients, unemployable because of the intensity of their symptoms, returned to full employment. Three of three patients showed a decline in HIV core antigen (P-24). Initially positive HIV cultures became negative in three patients. Clinical toxicity and side-effects were entirely absent. Acute toxicity studies in animals showed no toxicity whatever at dosages 100 times those used in the pilot human experiments. (McDaniel and McAnalley, 1988) These experiments, however, were uncontrolled, and additional studies, utilizing appropriate scientific study design would need to be done before the data would be acceptable to the scientific community.

In plasma there are four interacting systems which serve vital protective functions. These include the following:

The latter system, the complement system, consists of a series of proteins which require activation. When activated these proteins interact sequentially - a cascade phenomenon - and form circular, doughnut-shaped proteins, which are inserted into the surface membranes of bacteria, literally causing "holes" which permit the interior of the bacterium to become exposed to the environment, causing the death of the organism. Normally this complement system is stimulated by the presence of polysaccharides on the surface of the invading organism. Studies have shown that the polysaccharides (glucomannans) of Aloe can perform this function. (t'Hart et al, 1988; t'Hart et al, 1989)

There are several additional beneficial actions of ingested Aloe presented in the literature. True, many of the anecdotal reports have been studied in animal models, giving credence to the anecdotal information. Other reported benefits in human subjects have yet to be documented by scientific investigations. A number of studies are currently underway in various laboratories across the country and in other countries as well.

Three salient points are of vital significance in providing credibility to scientific studies: (1) How are the polysaccharides handled in the digestive tract? (2) As the juice is so "dilute" is there really sufficient material absorbed to account for the reported benefits? (3) What amount of juice would be required orally, on the average, to provide a beneficial effect?

The answers are: